Abstract The Cauê Aquifer is an important water supplier to the third largest urban agglomeration in Brazil. The Metropolitan Region of Belo Horizonte is in the Iron Quadrangle, site of intense iron ore mining, requiring large volumes of water and mine dewatering. In this context, we evaluate the regional impact on groundwater level between 2000 and 2019 based on a conceptual hydrogeological flow model on the eastern limb of the Moeda Syncline. This study includes the definition of boundary conditions and aquifer units, the calculation of hydrodynamic parameters, water balance, renewable reserve, and flow analysis. The Cauê, Gandarela, and Moeda aquifers are considered aquifer units, among which the Cauê Aquifer showed the highest hydraulic conductivity (9.45×10-7 m/s on average) as well as the highest recharge rate, with 38.67% rainfall. The average volume pumped was estimated at 41 million m³/year, equivalent to about 150% of the renewable reserve of the Cauê Aquifer, calculated at 27 million m³/year. Underground flow in the area tends southward, and the Cauê Aquifer acts as a water divide, which is less evident in the center of the area, where the greatest impact on groundwater level lowering occurs.